This page keeps track of new/upcoming treatment options for gout. What’s in development? What’s promising? What’s available soon? Find out below… Current topics include ABP-671, SGLT2 inhibitors, NLRP3, EATP, ABCG2, and more.
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News
- EMA issues clinical development guideline for new urate-lowering therapies (ULT) and anti-inflammatory drugs to treat gout Nov 15, 2019
- Potential new target for treatment of gout: Research team discovers alternate pathway by which MSU crystals trigger inflammation Oct 29, 2019
- Selecta Biosciences Presents Full Data from Phase 2 Trial of SEL-212 for Chronic Refractory Gout at EULAR 2019 Jun 12, 2019
- Gout patients suffer in silence with low expectations of treatment Jun 12, 2019
- Copper oxide nanoparticles have potential in the treatment of hyperuricemia and gouty arthritis May 20, 2019
- A new treatment for gout lowers the urinary acid level in the body Mar 21, 2019
- Dyve Bioscience Announces Positive Results from Pilot Study in Gout Pain Mar 20, 2019
- Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine – “Yokuininto lowered sUA through both increased uric acid excretion and decreased uric acid production” Mar 12, 2019
- mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: A prelude to a new add-on therapy? Feb 28, 2019
- FDA Approves Liquid Colchicine Formulation for Gout Feb 26, 2019
- ROMEG Therapeutics Receives FDA Approval of GLOPERBA® (colchicine) for Prophylaxis of Adult Gout Flares Feb 26, 2019
- FDA adds Boxed Warning for increased risk of death with gout medicine Uloric (febuxostat) Feb 21, 2019
- Anakinra May Be Effective for Treatment of Acute Gout Flares Jan 11, 2019
- Injected Drug May Be New Weapon Against Gout Sep 18, 2018
- Stimuli-Responsive Drug Delivery: A New Way To Treat Gout Sep 4, 2018
- Selecta Unveils Expanded Positive Clinical Data for its Gout Treatment Jun 15, 2018
- Tiny fish leading the way in a cure for gout Mar 28, 2018
Research
- Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis Nov 7, 2019
- Stevia residue extract alone and combination with allopurinol attenuate hyperuricemia in fructose-PO-induced hyperuricemic mice Nov 3, 2019
- Treat-to-target (T2T) of serum urate (SUA) in gout: a clinical audit in real-world gout patients Oct 24, 2019
- Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea Linn. leaves in a rat model of gout Aug 22, 2019
- Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney May 31, 2019
- Natural products for the management of hyperuricaemia and gout: a review May 16, 2019
- Inhibition of Hyperuricemia and Gouty Arthritis in BALB/c Mice Using Copper Oxide Nanoparticles May 12, 2019
- Leptin may serve as a novel prevention and treatment target in acute gouty arthritis Apr 22, 2019
- Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy Mar 13, 2019
- Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine – “Yokuininto lowered sUA through both increased uric acid excretion and decreased uric acid production” Mar 12, 2019
- Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome Mar 12, 2019
- Antiobesity and Uric Acid-Lowering Effect of Lactobacillus plantarum GKM3 in High-Fat-Diet-Induced Obese Rats Feb 22, 2019
- Polyphenols from Platycladus Orientalis (L.) Franco leaves show potential in prevention and treatment of gout Feb 19, 2019
- SGLT2 inhibition might be useful in the treatment of gout and gouty arthritis Feb 14, 2019
- Mori Ramulus (Chin.Ph.)-the Dried Twigs of Morus alba L./Part 1: Discovery of Two Novel Coumarin Glycosides from the Anti-Hyperuricemic Ethanol Extract Feb 11, 2019
- Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression Feb 6, 2019
- Phytochemical Analysis and Potential Biological Activities of Essential Oil from Rice Leaf Feb 2, 2019
- Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation Jan 7, 2019
- New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats Dec 18, 2018
- Resveratrol may have a potential therapeutic effect on gouty arthritis by inhibiting TAK1 activity Dec 8, 2018
- Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice Nov 24, 2018
- Disease‐Triggered Drug Release Effectively Prevents Acute Inflammatory Flare‐Ups, Achieving Reduced Dosing Jul 15, 2018
- Hypouricaemic effects of yoghurt containing Lactobacillus gasseri PA-3 in patients with hyperuricaemia and/or gout: A randomised, double-blind, placebo-controlled study Mar 9, 2018
Clinical Trials
- Phase 2a Study of AR882 Plus Febuxostat or Allopurinol in Gout Patients Nov 7, 2019
- The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adults Oct 25, 2019
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671 Aug 19, 2019
- The Effect of Tart Cherry Juice on Risk of Gout Attacks May 13, 2019
- A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671 in Healthy Subjects Apr 8, 2019
- A Study to Compare the Efficacy of SEL-212 to KRYSTEXXA® in Gout Patients Refractory to Conventional Therapy Apr 5, 2019
- Dietary Approaches to Stop Hypertension (DASH) Diet Effects on Serum Uric Acid (SUA) in Adults With Hyperuricemia and Gout Mar 5, 2019
- PKPD of Anthocyanins After Oral Cherry Juice Concentrate in Gout Patients Mar 5, 2019
- Pilot Study Evaluating The Efficacy Of Etanercept In Acute Gout Mar 4, 2019
- REduCing Immunogenicity to PegloticasE (RECIPE) Study Mar 1, 2019
- Placebo Controlled, Dose Escalation Study to Evaluate Safety, Pharmacokinetics & Efficacy of SAP-001 in Gout Patients Feb 27, 2019
- Pharmacogenetics of Sodium-dependent Glucose Transporter-2 (SGLT2) Inhibitors Jan 28, 2019
- Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout (MIRROR) Dec 21, 2018
- PKPD of Anthocyanins After Oral Cherry Juice Concentrate in Gout Patients Aug 28, 2018
- Pilot Study Evaluating The Efficacy Of Etanercept In Acute Gout Aug 17, 2018